Dissecting the Group of Common Variable Immunodeficiency Disorders

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A CASE REPORT OF COMMON VARIABLE IMMUNODEFICIENCY(CV ID) WITH LEUKOCYTES ADHESION DISORDERS (LADS)

A three year old boy with delayed separation of the umbilical cord, recurrent pyogenic infections and common variable immundeficiency is presented. The immunoglobulin measurement was severely abnormal. To the best of our knowledge, the existance of leukocyte adhesion disorder together with common variable immunodeficiency (CYID) in a patient has not been reported prior to this study.

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Common variable immunodeficiency.

Common variable immunodeficiency (CVID) is a form of severe antibody deficiency with an estimated prevalence of 1 in 25,000 to 1 in 100,000. The disorder apparently results from currently undefined immune deregulations resulting in failed B-cell differentiation with impaired secretion of immunoglobulins. A 5-year female presented with fever, cough and shortness of breath at rest. Past medical h...

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Common variable immunodeficiency

Common variable immunodeficiency (CVID) is a common primary immunodeficiency characterized by a failure in B-cell differentiation with defective immunoglobulin production. Affected patients are uniquely susceptible to recurrent infection with encapsulated organisms and have an increased propensity for the development of inflammatory and autoimmune manifestations. The diagnosis of CVID is common...

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ژورنال

عنوان ژورنال: Clinical Infectious Diseases

سال: 2009

ISSN: 1058-4838,1537-6591

DOI: 10.1086/606057